rampancy: It also doesn't work as well for newer indie releases or re-releases of classic titles like Turok. Underrail is another example of such a game. I've heard some smatterings of positive results in WINE from people who've run the demo on it, but I've also heard of issues with performance as well as the game's reliance on .NET 4.
Regarding .NET 4 and XNA 4.0 since I've seen one runtime require the other at times :)
I've managed to get games that require .NET 4/XNA 4.0 running under WINE 1.8-rc2 (haven't tried WINE 1.9.0 yet...) after running "winetricks dont40" and "winetricks xna40". Case in point: Sword of the Stars: The Pit and Dungeonmans, which are both .NET 4.0 games :)
Gydion: This is the thread where we all bother
JudasIscariot, haz de games, by asking does GOG GAME run in Wine? Alternatively, if you own the game and have tried yourself (Judas™) feel free to post the Wine version, any needed winetricks, GPU drivers, etc.
This runs in Wine:
To be updated You can ask me all you like but do keep in mind that this is all unsupported by GOG and is quite unofficial :)