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Win10x64 here.
DxWnd v2.06.00 breaks the game completely with default settings and I wasn't able to find a good setup.
Wine3D v2.7 (possibly with staging patches) gets the game to work but task-switching breaks it.
dgVoodoo v2.82.2 gets the game to work with task-switching.

No Windows compatibility settings made any meaningful difference in my testing.