Ashkc88: So far the following GOGs work great on my 64-bit Windows 7 machine without modification other than compatibility mode:
Battle Chess Special Edition
Beyond Good & Evil
Blake Stone: Aliens of Gold
Blake Stone: Planet Strike
Blood, One Unit Whole
Blood 2: The Chosen
Descent 1 & 2
Descent 3
Duke Nukem 3D
Duke Nukem: Manhattan Project
Earthworm Jim 1 & 2: The Whole Can of Worms
Evil Genius
Fallout
Fallout 2
Fallout Tactics
Far Cry
Guild: Gold Edition, The
Heroes of Might & Magic II
Heroes of Might & Magic III
The Incredible Machine
King's Quest IV, V & VI
Might & Magic 6 Pack Limited Edition
Myst: Masterpiece Edition
Painkiller: Black Edition
Port Royale
Postal: Classic and Uncut
Postal 2 Complete
Prince of Persia: The Sands of Time
Psychonauts
Red Baron Pack
Redneck Rampage
Rise of the Triad: Dark War
Shattered Steel
Simon the Sorceror
Space Quest 4, 5 & 6
Unreal Tournament GOTY Edition
Games that need tinkering with:
Die By The Sword - Has graphical flickering.
This mod fixes everything.
Gothic 2: Gold Edition - The intros don't work, but the game plays fine. It's worth mentioning that I have an Nvidia card.
Games that I have, but haven't tried yet:
Freespace
Freespace 2
It's worth mentioning that I have UT 2K4 on disk and it works fine on Windows 7. The GOG version shouldn't have any problems.
an added note the build based titles require you to set the run as ADMIN box under compatibility settings.