Definitely this one.

I could never solo hardcore ladder diablo 2, past middle Nightmare setting.

Even though my chosen character was said to solo even ladder Hell setting.

There are a bunch of mods that solve that but the important one is SkyUI. This and super precision timing. I avoid games that rely on this and try to circumvent them in anyway I can so in general they aren't so much as a problem as an inconvenience that I have to deal with.

Why? Its effect is subtle with a medium to high performance hit but I like it.

Funny how most issues mentioned here are rather common when the OP asked for weird problems.

That's why I made the post I did. The NES baseball thing wasn't bad, and really not even a problem, but it was so damn weird, so I mentioned it in here.

I still have a thorn in my sphinctor over GTA:Vice City.

I bought that game when released on the PS2 and felt the missions in it were a bit mad. When I got to the motorcycle one, where you had to jump from building to building just to get on top of a 2 storey station to activate the searchlight porn advert, only for a ladder to drop from the roof afterwards really pissed me off.

I was so disgusted with it that, even though I'd done the mission, I couldn't play it anymore. I removed the disc from the drive and threw the game in the bin. It put me off the GTA series forever.

I sometimes nitpick/overthink stuff. Or at least that's what people who don't care about such things call it. For example I couldn't get around the nonsensical design of the space station in The Swapper. The place is supposed to be an actual space station were people lived and worked, but is a nonsensical maze of rooms that serve no other purpose than to be puzzles, and is impossible to navigate without a gadget that no one had, or even knew of when they built it. It doesn't help that the game is very monotonous, slow and colorless, so there are many reasons I disliked it, but that first one is probably the "weirdest".

It's not the only such problem I had, by far. I had tons of these about Bioshock Infinity, a game that makes no sense whatsover, but while the main story full of plot holes is one thing, the fact that police officers in that city apparently get buried with bananas and other junk and food shoved in their pockets, and rockets are just laying around in garbage cans is a whole different level of stupid.

It even happens in games I like. In Divinity Dragon Commander I just could not help but pause and question why do Lizardfolk women have boobs? They are lizards, not mammals.

Figuring out where to go next after finishing a game.
There is this awful period of being shellshocked where I have no idea what to do. This process can take hours of active thinking, having to weigh time constraints with the possibilities.

Here's two: weirdest thing that put me off a game, and weirdest problem solving I've done in a game.

I hated "Deadlock II" for years for it's pop-up menu style interface. Let me see the buildings I'm managing! Couldn't stand it, and despite loving the first game I abandoned it after 2 tries. But years later, I learned it has an entire campaign for each of the 7 races. Wow, so impressive I went back and have played it for tons of hours (even made my own maps). I guess an old interface doesn't look so important now.

Space Empires IV presents the weirdest problems I've solved. The game lets you build modular spaceships that are so flexible... you can make defective spaceships. Like my massive floating space factory, ready to build fighters. But who neglected to add a fighter bay? Well, I didn't win points for realism, but I parked a ship with cargo holds and fighter bays next to it, and did cargo transfer followed by fighter launch. Whatever works, I guess. Similar problems with not enough fuel (build a ship that regenerates fuel quickly) and other weird combinations of ships have made it quite the weird problem solving exercise.

Any game where gameplay is intentionally sacrificed for some aesthetic aspect has a high probability of being disliked by me.

A prime example of this is Amnesia. The game deliberately cripples the controls because it's supposed to contribute to the whole "scary" feeling - but I don't get scared easily by a game. All I saw was a game that *didn't want me to continue playing*. Stars!: between approx. 600-1000 systems/planets in a "HUGE" game (depending on universe density), which is suitable for up to 16 players.

Sadly not all that easy to run on a modern system, since it's a Windows 3.1 game.

I own the disc for that. Every night I look at it and weep.

In GTA Vice City, if you select an incompatible sound option, the back of the car (every car) will drag down on the ground when you drive around. Select the correct sound options and it works fine. It makes no sense.

In certain GTA´clones, I don't feel like playing the game because different parts of them really need different controllers. It just feels silly and awkward for having to swap controllers for different parts of the game.

This was quite bad in e.g. GTA San Andreas (and possibly Vice City), which otherwise played quite good with keyboard+mouse, but the flying parts really needed a gamepad. Driving also benefited from the analog gamepad controls, but it wasn't a must for them. I recall feeling the model biplane parts in GTA SA were near impossible, until I tried with a gamepad and they became quite easy. The funny thing was though that whenever the plane landed and I wanted to steer it on the ground, I wanted to swap back to keyboard + mouse, as it was somehow easier to control there. :)

Using a gamepad for everything is not an option either, as then aiming and moving on foot sucks with it. It feels much more natural and instant with keyboard + mouse.

Saints Row 2 has been sitting there for a long time due to this. Now I am driving with a gamepad wroom wrooom... oh need exit the vehicle and get on foot, rushing to keyboard + mouse...

Starting and/or finishing main campaigns in games. I'm a freak for sandbox mode. Can't help it, I'm spoiled. Any game that offers a sandbox mode ends up being played in sandbox mode. I don't think I've finished a scripted single player campaign in a game in a year or two, and even back when I did it was sporadic.

Seconded. Or it's a quick game of solitaire as I can't even be bothered to play a "complicated" game. Pac-Man is too complicated for me sometimes. ;)