I'm pretty sure Assassin's Creed: Director's Cut GOG works in Wine. In fact, I finished the game and it came with controller support as well. :D
Here's the appdb entry: https://appdb.winehq.org/objectManager.php?sClass=version&iId=28057
Some notes from my blog:
$ winetricks d3dx9_26 d3dx9_28 d3dx9_31 d3dx9_35 d3dx9_36 d3dx9_39 d3dx9_42 d3dx9_43 d3dx9 directx9 physx vcrun2003 vcrun2005 vcrun2008 vcrun2010 vcrun6sp6 vcrun6 wmp10 xact_jun2010 xact xinput
Using the GOG installer, I used /verysilent parameter.
Run Assassin's Creed using the Direct3D 9 exe.
While playing I used 1.7.27 and when I upgraded to 1.7.30 (at the time), the sunlight became too bright, so that seems to be a regression. Reverting back to 1.7.27 resolved my issue. ;-)
Controller support was done by using x360ce on the same Wine folder as AC.
System: Kernel: 3.13.0-79-generic x86_64 (64 bit) Desktop: Gnome Distro: Ubuntu 14.04 trusty
Graphics: Card: NVIDIA GF108 [GeForce GT 430]
X.Org: 1.15.1 drivers: nvidia (unloaded: fbdev,vesa,nouveau) Resolution: firstname.lastname@example.org
GLX Renderer: GeForce GT 430/PCIe/SSE2 GLX Version: 4.4.0 NVIDIA 340.96