So finally I decided to dive again in Arcanum, I installed all the patches but the game has slowdowns, especially when when I choose an answer or when I run around in an area.
If anybody has an idea where it comes from...
Also, my OS is Windows 10.
Thanks in advance.
EDIT : well if there are still slowdowns while selecting an answer, it seems there is workaround which make the game more bearable (especially when you are running around the map or fighting) : go to the folder where the game is installed, right click on the launcher icon, in the "compatibility" tab select "run as administrator".