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What you used to unninstall nvidia driver, DDU? What version of windows 10 do you use?
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pigulici: What you used to unninstall nvidia driver, DDU? What version of windows 10 do you use?
Yes I've used DDU. I've Windows 10 Pro version 1809.
Then try the amd card and post the result.
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pigulici: Then try the amd card and post the result.
It definitely does not depend by the RTX2000 series GPU. I've installed my old video card but the problem remains exactly the same in all the possible combination I tried before. Maybe could be the last windows update version 1809?
Did you installed directx9?
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pigulici: Did you installed directx9?
Yes, I've installed the pack suggested by GOG support.
Not sure what to say, maybe try windows 1803, as a side note, tomorrow I want to install 1809, and I will try to test W2, I have gtx 1080.
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pigulici: Not sure what to say, maybe try windows 1803, as a side note, tomorrow I want to install 1809, and I will try to test W2, I have gtx 1080.
Just a moment ago a friend of mine tried to install The Witcher 2 on his config, a lot like mine with RTX2080(Last Nvidia Driver) and Windows 10 Pro version 1809. It works nice. I really don't know...
Hello I'm here againg, this time with good news!

Finally the game has started. In order to make it happens I've attached the Visual Studio Debugger to the crashing executable (witcher2.exe) it has suggested me an expection that involved hid.dll. This library is responsable of USB peripheral communication so I decided to uninstall all the peripheral USB driver related (Mouse, Keyboard, SoundCard ecc...) then I managed to reinstall one driver at time and I finally turn out the the issue was caused by mouse's driver. In particular the driver was Roccat V:1.20 FW:1.21 for Kone XTD. So I've reinstalled all the drivers except of the mouse one.
I hope this will be helpfull for some future issues.

Thank you all for the support.
Post edited December 24, 2018 by formich93
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formich93: Hello I'm here againg, this time with good news!

Finally the game has started. In order to make it happens I've attached the Visual Studio Debugger to the crashing executable (witcher2.exe) it has suggested me an expection that involved hid.dll. This library is responsable of USB peripheral communication so I decided to uninstall all the peripheral USB driver related (Mouse, Keyboard, SoundCard ecc...) then I managed to reinstall one driver at time and I finally turn out the the issue was caused by mouse's driver. In particular the driver was Roccat V:1.20 FW:1.21 for Kone XTD. So I've reinstalled all the drivers except of the mouse one.
I hope this will be helpfull for some future issues.

Thank you all for the support.
Thanks for feedback.
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formich93: Hello I'm here againg, this time with good news!

Finally the game has started. In order to make it happens I've attached the Visual Studio Debugger to the crashing executable (witcher2.exe) it has suggested me an expection that involved hid.dll. This library is responsable of USB peripheral communication so I decided to uninstall all the peripheral USB driver related (Mouse, Keyboard, SoundCard ecc...) then I managed to reinstall one driver at time and I finally turn out the the issue was caused by mouse's driver. In particular the driver was Roccat V:1.20 FW:1.21 for Kone XTD. So I've reinstalled all the drivers except of the mouse one.
I hope this will be helpfull for some future issues.

Thank you all for the support.
https://www.gog.com/forum/the_witcher_2/cannot_launch_the_witcher_2_windows_10/post24

:)
How can I mark this thread as solved?
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formich93: How can I mark this thread as solved?
Hover over the reply you wish to mark with your mouse and you'll see (at the right) "Mark the question as answered", or words to that effect.