When I am trying to start Syberia 2 I get this message "3D rendering engine could not be initialized" I tried to lower my screen resolution but without successes. I am running on Windows Vista. Does anyone here have any ideas on what I could try to make this work?
800*600 is the game's default resolution, I think. It cannot be changed. Your graphics card just scales the image to fit the screen, your resolution shouldn't matter.
Try reinstalling the game in a folder other than Program Files. If that doesn't help, you could try running the game the way Elqui said. Make sure to use NT4 compatibility though.