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kroetenschemel: I have a strange bug with Spelunky, when I try to start it, it crashes right away, when I try again, it works perfectly fine and stable, then when I exit and start again, it crashes, after that it works again.
This doesn't keep me from playing because I just have to start the game twice in a row, but it's weird anyway.

Has anyone else this problem or knows how to solve it?
I'm using WinXP and Xpadder.
Are you using a non-standard controller? I ask because if you're using an Xinput controller like the Xbox 360 one, then you don't need to run Xpadder :)