Not sure about PC either - i'm running from within GOG. I love the game, im now on MacOS Sierra - and when ever i click the icon it doesn't load. To add to this i have also uninstalled and installed and no matter what i do it won't load. I would be interested in if anyone on mac sierra has it working... ?
This has been solved. Per support, you'll need to download the Wineskin Winery and run it to make sure you have the newest engine and wrapper versions. Open up your Applications folder in Finder and right click on QFI, select show package contents. Go Contents, Resources, Game, right click on the app and select show package contents again, and you should see Wineskin.app, possibly with QFI's icon. Run it, select advanced, then tools, Change Engine Used (to the newest) and then Update Wrapper.
Unfortunately, these instructions won't work as of now in macOS Catalina (10.15). Wineskin has not been updated to 64bit, so it won't run until it is. Even if it were, it's a little ridiculous that this game requires a user to jump through hoops when the developers should just issue an update.
As it is now, this game will not run on macOS Catalina, and this should be noted on the store page for the game.