If you have downloaded a game and cannot get it to work on a supported OS, GOG support will try to help you in getting it to work. If they're not successful in helping you getting the game to work, you get a refund.
You can also get a refund if you have not yet downloaded the game, and you ask for a refund within 30 days of buying it.
Additionally, you can get a refund for an in-dev title, for any reason (regardless of whether or not you have downloaded it), within 14 days of purchase.
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If you have downloaded the game, it works, and it was not labelled as in-dev when you purchased it, you most likely do not get a refund.
You can always ask support, but I'm fairly certain you'll get a "nope".
Post edited September 30, 2017 by Maighstir