A young orphan girl with a big robot companion in a large dystopian half-cyberspace city, trying to survive. That's quite a premise to work with and the devlopers did well.
The world created by this game is interesting, humorous and sometimes quite dark and shows a lot of meta-gaming (which I like), without it being disturbing.
If you know Bladerunner you will see many hints of it, but they are subtle. The same goes for Ghost in the Shell and other classical movies. The designers made no effort to hide that, and it fits.
The puzzles are standard adventure-like, even though a bit on the easy side. I think in the later versions the size of the mouse-over spots was increased, abandoning the pixel-hunting you had to do before.
Travelling between locations is a big aspect of the game, and you do more travelling than item-hunting, which serves to emphasize the point of a little girl lost in a big world.
Some hardcore adventure players may dislike the lack of complex item-puzzles and some places only having one item instead of being loaded with dozens of them, but I like this deviation from tradition. It's the story the games focusses on and not so much the puzzles.
One obvious negative spect, already mentioned before, is the lack of spoken languages other than English. As the game takes place in Berlin a German version would be obvious, of course.
Still, the voice actors are good, some are very good, and the German translation is ok most of the time.
There are secrets hidden in the game, which you can find or not, but have no influence on the story. That's fine with me. Sam (your robot) serves as your hint guide, but I found no need for that, as verything he can tell you get told anyway.
Ok, the political aspects of the game can't get unmentioned but they are done in such a satirical and sometimes cynical way that they're not disturbing and fit with the story and the setting.