Before I started playing, I followed the advice on Bethesda's official site. I set compatibility to Windows XP service pack 3, I ran as administrator, and played in windowed mode. I finished the base game and 3/5 of the DLCs so far (played 53.5 hrs). I made sure to save often as I was playing. I crashed in total about 8-9 times in those 53.5 hrs. Fallout 3 is a great game. I had it on the xbox 360 but never got the chance to play the DLCs. I picked this gog GOTY edditon on sale for $5 and it was definitely worth the risk whether or not it would work on Windows 10.