I played it on difficulty 0-1-2-1 (which means zero combat and simplified game objectives), and I still needed a walkthrough at times. For a first-time playthrough, I'd recommend not going higher than 1-2-2-1. I can't imagine playing it on the default 2-2-2-2 difficulty - the combat just feels too clunky to me. I'm glad I finished it, but I have absolutely ZERO plans to ever return to it.
There are many great things to say about the Blood itself, but after finishing it, don't forget to play fabulous mods like Death Wish (true Blood 2 if you ask me - some of the levels are even better than in the original Blood) or Marrow
