I've only played it for a few hours, but Dungeon Siege works through Wine64 5.0.3 on Linux 5.11.0 in POP_OS! I've put the versions just in case but I think it is not very version specific. The GOG installer complains about no .NET but I just used the setup_* files. You do get an error message on completion but the game works fine. Now I get to play DS again years after finishing it on release. Woo