Everything op_2019_si said, I have experienced as well. I just started the game tonight and have had 5 or so lockups/crashes in my first session. Any time I died, or finished a mission/had to load cutscenes. It at least saved progress so when I loaded back in I was at the start of the new mission. I'm missing certain in/outro cutscenes though. I hope something could be done about this as I don't see myself finishing it in this state. I've read various fixes including updating directx and playing the game in windowed mode. I haven't tried the latter.
