I would have written this yesterday but I spent too long breaking out of vault 111 and stripping down Sanctuary, just like old times. I have a Debian based Linux OS and use Lutris to run ".exe" games. With Runner: lutris-GE-Proton8-13-x86_64, it worked out of the box! That said, as an old habit I run borderless windowed mode at full res instead of full screen. I have not tried full screen. I cannot wait to experience again the absurdity that is Nuka World!