I had constant crashes, looking on forum there multiple solution. After while I found two possible workarounds: 1.) For me (AMD CPU + GPU) game crashes when using fullscreen, no crash in window mode. 2.) Limit/Set affinity for Bioshock HD process only for two CPU cores (Looks like this issue is related only to CPUs with more than two cores, hmmm :) Bonus: Use F11 for Quick Save My personal rating without crashes would be 5/5.