Warhammer 40,000 is ripe for a great many Role Playing Games, and no part of it is as open to such a game than the Rogue Trader mythos. If you like Warhammer, like outer space and enjoy pirates, this is a great game for you.
While most of the jokes are a little dated with regard to culture, the jokes making fun of Superheroes in general and comic book heroes in particular are as timely as ever with all the Marvel Movie Madness happening. The interface is a bit clunky coming form last century, but overall the system works well.
