This game would not start up at all for me. The only way to make it work was to install the mod "A Tale of Two Wastelands". Unfortunately, that needs you to also own Fallout New Vegas. Fortunately for me, I did - both on GOG. Once I had installed that mod, when starting up the game up I needed to start a new game and then load my save game rather than load my save game straight from the menu. After that it ran fine.
