You can play out of the box, however before I exit the vault, the game crashes. I use Windows 10, but as I understood the reason is the multi-core CPU. A fix for this is: - Open My DocumentsMy GamesFallout3FALLOUT.INI - Find bUseThreadedAI=0 - Change to bUseThreadedAI=1 - Add new line iNumHWThreads=2 PS: This also happens on the Steam version, so not GOG's fault.