I do not know who this will help or if it will help. But I tried everything I could find to get my game just to not crash loading it at all. I found that deleting the Fallout.ini in the My Documents -> My Games -> Fallout 3 made my game work. I do not know why but it did. I run Windows 10 with a Nvidia GForce GTX 1080 card and I have it set to ultra video settings. Also check and make sure that when you run launcher you set your screen resolution and if it still crashes set the Anisotropic Filtering from 15 Samples to 7 Samples which seemed to make it work fine. I have not gotten to play it yet which I did when it first came out and loved it then so I know what its about and its one I go back to and play many times and hope to continue to do so. I really hope this helps other people out.
