Aside of a review about the game itself, I'd like to share about mod support of this. First, GOG version of Fallout 4 binary (Fallout4.exe) is virtually same as Steam version except Steam stubs. It even requires steam_api64.dll to run and GoG version has steam_api64.dll but it is a wrapper of galaxy client API. It means... GoG version has same bug that Steam version has. You will get darker face bug with some texture replacers, nvidia gameworks related crash on RTX 3000 series or later and goes on. In short, yes GoG version has no problem to use with F4SE. However, if mods are not working correctly, check fallout.ini and change or add following line in [ARHCIVE] section: bInvalidateOlderFiles=1 sResourceDataDirsFinal= Then all the mods can be used right away. Note to "Buttout" f4se plugin: Use "OnProcessAttach" for LoadMethod in "xSE PluginPreloader.xml"
Even I already possess LE with all DLCs, Special Edition with anniversary updates on Steam, I bought again. Yes basically Todd made me to buy Skyrim once more. Joke aside, since it is DRM-free, as other games on GOG, it works really good. Starts faster, You don't need to run Steam, most of mods including SKSE plugins support GOG Skyrim too. So if you have any plan to mod this game heavily don't worried about the compatibility. (Unlike Windows store and Epic Store version especially) Also you are a hacker who interested making SKSE plugins, the binary is not packed and do no any shenanigan so it is really easy to attach debugger/disassembler to write SKSE plugins. 10/10 would buy it again. And I would be really happy to buy again if Fallout 4, Starfield and TES 6 gets released on GOG.