Just finished the game. I am running it on windows 7 and have been lucky to have no issues whats so ever. Just wanted to say what a fun quirky game!
I did not have any issues running the game. However, the game has a great presentation, and feels like a living comic book. However, the campaign is really slow and levels are too small. Got bored after reaching that level where we have to escape through the Wire lift in the Ice filled place. Then, just removed the game.
May be I will come back to the game some other day, but I felt it was boring.