danaimforthehead: just wondering if you ever got this problem fixed and how. I just keep getting the same message "Xanadu Next has stopped working" at launch. I even tried GOG support and nothing.
irrotation: I had this problem too. Tried running Windows compatibility troubleshooter for XANADU.exe, and apparently the game needed Windows 8 compatibility mode to work (I'm using 64-bit Win10). I haven't tried if the actual game is without problems yet, but at least I got the see the title screen.
Edit:
Actually, it seems like you don't need compatibility mode. Running the game without GoG in-game overlay is enough.
It worked, thank you so much! Just launched the game directly through the game file, without using GOG, and it finally worked. Again, thank you!