The aiming to hit the Buttons on the Panel is WAY off, and I cannot press 1,3, or 6 which is Gamebreaking bcause you need to ride to floor 6 since the Airvents for Hannahs Apt. are locked until you get inn there.

Known Bug? Or does anyone have a Workaround (Console command or other)?

Kinda stuck here, since I cannot complete the Plaguebearer Questline.

This is probably caused by the most infamous Bloodlines bug: that map gets messed up if you play long sessions in one go, like more than two hours. Quit the game, restart it and load an earlier save!

By the way this is a game engine bug, which is why a fanpatch cannot fix it.

The game runs as a 32 bit executable, i.e. it cannot address more then 4 GB of RAM, no matter how much memory your machine actually has.

But because there is this memory leak, more and more memory gets lost, until its all spent, and you have to restart.

Thats why after about 2 hours you should always completely shut down the game and then restart it.

OMG Thank you Guys SO much...
Worked like a Charm, thankfully I had a "recent-ish" Save at Hand