If you are using AMD GPU with Mesa, you can improve Bloodlines graphics (when running the game in Wine) by forcing anisotropic filtering.

Set environment variable R600_TEX_ANISO=16 before launching wine. In PlayOnLinux it can be done in Configure > Miscelaneous > Command to exec before running the program.

export R600_TEX_ANISO=16

Note, this applies to radeonsi driver as well as to r600.