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Ishbane: Played around with nglide settings and tried multiple combinations of programs running in system tray.

It all boiled down to Logitech's SetPoint, killing it beforehand allows me to play Uprising flawlessly.
Can confirm killing SetPoint allowed me to play the game.
Hope folks have noticed that this game has been updated. Does not seem to say anywhere on GOG what the update is but having downloaded and played the newer version I've found it less prone to crash.
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branbuds: Hope folks have noticed that this game has been updated. Does not seem to say anywhere on GOG what the update is but having downloaded and played the newer version I've found it less prone to crash.
Unfortunately I'm still having issues. Crash on the splash screen. Can't figure out the problem for the life of me.
I use Windows 10 64 bit. Since I have purchased the game I have not been able to load it into the main menu. Every time it crashes on the loading splash screen. I have tried closing down all unnecessary background programs and startup programs and still have not had any luck.
I had a similar issue, I've found that making sure there are no active windows open on my computer lets me into the game to play but I am encountering control issues. The mouse is not being captured by the game and when I try to move it around it will go out of the game window, and then the game minimizes while the desktop is the active program.