Any luck running this on wine ? (Mac)
I tried with the demo with no success at all. Granted I'm not an expert at it or anything but maybe it's not possible ? :-(

Got it running on Debian GNU/Linux 7.0 "Wheezy" x86_64 with Wine 1.4.1.

You should install it into a clean prefix, e.g.:

$ export WINEPREFIX=~/.local/share/wineprefixes/unmechnanical
$ env LANG=C winetricks sandbox
$ cd $WINEPREFIX/drive_c
$ cp ~/Downloads/*unmechanical*.exe ./

Installation:

$ winetricks gdiplus d3dx11_43 xact_jun2010 dotnet40
$ wine setup_unmechanical_1.0.2.18.exe
$ wine patch_gogpackunmechanical_1.0.3.19.exe
(gdiplus is for the patch setup and the others are required to run the game)

Problems:

The focus is lost on start, you have to Alt-Tab into the game.