Game installed, but nothing happens when I try to launch the game from the UI.

I've seen the posts suggesting that there's a missing package, but every one of the required packages (libxcursor1:i386, etc.) says it's currently installed and is the newest version whenever I go to add them.

/.config/unity3d is missing an Obsidian Entertainment folder, so it's not even getting far enough to write it.

Running: Mint 18 (64-bit), EVGA nVidia GeForce GTX 1050 Ti, nVidia driver version 375.10

Did you check the game with ldd?

Try Running

$ ldd -r ./Tyranny

from the "game" directory in console.

Thanks for the suggestion, but I managed to find a solution: manually reinstalling the nVidia drivers and answering 'Yes' to the 32-bit library compatibility prompt. It works now, as do a couple other games (Hotline Miami, Papers Please) that had the same issue. (I hadn't realized it since I hadn't tried launching them on the new build - every other game I have worked.)

Oh! I would never thought about that. It is a rare case; not many people use nVidia-provided drivers due to extremely convoluted install process and problems with kernel updates, even less people are refusing to add 32-bit compatibility. Though I do use nVidia packages, personally I always install 32-bit compatibility stuff so I did not experienced any problems before. Will know this potential source of problems!