I am getting this error on my Eyefinity setup when I try to run the game.
If I run the game TotalA.exe -d it works but only to a max resolution of 1600x1200 so I know the game works but it is having trouble with the Eyefinity setup. I would love to be able to run this game in my 3600x1920 resolution but like I said it will not Initialize. Anyone else out there with an Eyefinity setup get this game to run?

Bringing this thread back because I just bought the game and I'm getting this error.

You can control the resolution from the registry. Im running 1440p. Run the game in windowed mode (-d) and define the desired resolution in the registry. Search for 'Total Annihilation' in the registry until you find the settings hive (mine is at [HKEY_USERS\S-1-5-21-1022533655-2654835114-1722964594-1001\Software\Cavedog Entertainment\Total Annihilation]), then adjust the "DisplaymodeWidth" and "DisplaymodeHeight" values. Careful tho, they are in hexadecimal by default.