Got the same problem: Save screen keeps showing a rotating symbol that looks like it's some kind of wait cursor. But I can select Empty Slot and save the game. When I try to load, I find I cannot even select [Load].
Also, after starting up the game again, the [Continue] option is disabled. The only way to get back into my old game is quick load (F9).
I wonder if this is due to my beta installation from Steam: I now claimed the GOG key instead, and because I didn't know how to go about the installation, I simply left the beta installation and reinstalled via GOG. Maybe the save folder settings are now messed up, although the beta save folder still exists - so if it's looking in that place,
it wouldn't explain why load doesn't work at all.
P.S.: Just tested to start a game and save the Steam version. Same problem. I'm now going to uninstall both, and see if a fresh installation will fix it...
P.P.S Uninstalling both and reinstalling the GOG version didn't help: when I save at the broken dome (first area), I don't see existing saves, but the game still asks me to confirm that I want to overwrite an existing save. After saving, the load button still remains disabled though. Just as before. :-(
Actually, InXile give a warning that after the last beta patch the savegames were to be not compatible with the first official release version of the game. So probably, is a good idea to uninstall and erase that folder.