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MagicBoy: F1 options working fine for me (win7 64bit). I haven't tried it with ScummVM v1.8.0, what GOG installs (I use ScummVM v1.8.1).
Just double checked: The version of ScummVM that GoG has bundled with Toonstruck is 1.7.0. That version doesn't have the possibility to access the options menu by pressing F1.