FYI, fbo is the default setting.

As matter of fact, I am not sure why it is suggested in the winehq page. But it is so quick and painless to execute it that I did anyway.

See the winehq page.

Likely, old instructions (HOWTO), but it won't hurt setting it. A clean prefix with any remotely recent version of Wine will already be using it so it's not necessary to do so anymore.

I pretty much use a different wine prefix per program, if you disable mscoree and gecko (if the program does not need them, of course) the wine prefix is fairly small and you can set up and install libraries and overrides with ease. Besides doing so, different programs with different setups do not interfere with each other.

I use this two scripts:
init_wine.sh to create a wine prefix
and start_wine_exe.sh to activate it and use the programs inside.

I also have an issue, but on a Mac. I installed this using porting kit (www.portingkit.com), but it doesn't even launch. I used wineskin test run and got a log (attached) saying it couldn't locate certain dll's, although they are there (I checked).

What could it be?

Hey there!

I had the same problem, and after multiple hours of troubleshooting I can say that I fixed it!

After installing the game, right-click it in Porting Kit and go to "Advanced Tools", then click "Launch Wineskin App". From in there, click on "Advanced", then in the "Tools" tab click on Winetricks under the "Utilities". Unfold the "dlls" tree, and select both "mfc42" and "vcrun6", then press "Run". After it is completed the game should run. Be sure to select the "Legacy" version in the Titan Quest Launcher and not the "Enhanced" version, as the latter will crash.

Happy gaming!