Make sure you set Keep Aspect Ratio in video driver.
Remove any compatiblity from GOGsettings and DosBox exe's (fullscreen optimisation or anything else set by GOG).
You can use this tool to check what compatibility use (most not available in properties, especially in Win8\10).
Set adminrun to both exe or only to GOGsettings and use it (one of the settings lnk) as laucnher.
Install current DosBox to system. Copy DosBox folder conetnt to DosBox folder in GOG DOS-WIN version (almost similar to DOS-MAC). Try this dosboxTH.conf file... http://yadi.sk/d/vgEu8rmtMnK3Hg
At least i cn put link to AppCompatibilityChecker by Verok http://drive.google.com/file/d/16ljD92B1jPIT_bi1bh3pppBVAudkIj4Y/view
Check other threads. Some rooms can do some bugs with patients or surgeons. Also all levels time limited - after some year game stop generate patients - and if player continue "play" - CTD or freeze.