I had been through the ringer in trying to get the game to launch consistantly. Like, before switching over to GOTY, there was like a 4/10 chance that A: the game would run modded and a 2-3/10 chance that B: the game would run modded and properly display all of my mods. Even with the patch that makes the original game and DLC essentially the same as the GOTY, the game was basically dead for me. After transferring over to GOTY though, I'm hitting 100%. I haven't had a single time where the game didn't launch.
It's anecdotle, but, for me, the game is much, much more consistant when played GOTY for mods.