Okay, I've currently got an AMD R9 295x2 in my rig and I'll start this thread off with some quirks that I'm seeing, in the hope that they might be passed on and fixed wrt updated Driver

1) Crossfire - self explanatory, obviously needs a CF profile, Witcher 2 profile doesn't seem to do much for issues

2) Post/Processing antialiasing making the game shudder when paused - If I press ESC to go to menu sometimes the image is flickering like the camera is ever so slightly juddering

3) White flashes - every so often the screen will appear to flash pure white probably even for just a single frame.

4) Cutscene video when continuing game seems to run about 27fps, causes juddering.

5) Hairworks runs like lard on AMD(you guys obv know about this already)

6) on a 21:9 monitor - unable to expand HUD to full screen as target moves further from center the icon and the object start to drift apart, because the HUD is 16:9 to the screen 21:9 viewport

7) Post process AA seriously kills framerate - any chance of having a slider like with Ambient Occlusion

8) Textures flickering between darker shades - saw this around the riverbank where the old lady wants you to go into the house to get a pan. In game time was about 1am-ish - sandbanks flickering as though light was alternating back and forth on the surface

Not all bad things though..... Eyefinity over weird triple screen resolution 6160x1080 works a treat, bar the obvious hit to framerate, so thank you for that.

If anyone else has anything to add.... away you go.