When using a custom user.ini file, ignore whatever the actual configuration tool tells you. What matters is what is written in the user.ini file, nothing else. (I don't know if it actually makes a difference, really, but people keep saying to set the file to read-only, as well as to make sure the top of the file reads: CustomRenderingSettings=1 / PerformancePlatform=1. Like I said, I have no idea if it actually makes a difference, but it can't hurt, at least.)
You seem to be experiencing the exact same problem as I am experiencing, however. I started a thread about it:
Odd Graphical Issues - The Box of High Detail Textures. So you can check there for the ongoing discussion. I recently updated the topic with a response I received from TW2 tech support. There they explained that it is a feature within the game to lower the detail on textures in the periphery of the screen - you're not even supposed to notice it, unless you're really trying to look for it. In our case, however, this does not seem to be working as it should, as this 'box' is really small and limited, right in front of Geralt's feet sometimes. They haven't had many reports about this, but at least they've confirmed something is wrong, so they will take a look at it.
I didn't notice this during my first playthrough, either, but that might just have been a fluke. Like you, the game version doesn't seem to matter, but I am also using an Nvidia graphics card, and the only thing I can think of is that an update from 270 version drivers might have caused this problem to occur. It's just pure speculation, however, that I've thought of in retrospect while looking for solutions. Rolling back the driver version has not helped so far.