I was one shot (literally full vitality bar) by the Krayen on my first attempt. Not really sure what happened there as I certainly didn't take that type of damage on my second attempt.

Otherwise, less "best", and more "wanna tear my hair out", was when I was in the mine with the three dwarves, they somehow managed to block me into a corner with two mobs and no amount of pushing could get me out. :/ Suffice to say, after loosing all vigor to blocking, I sat there cursing companion NPCs, especially since they're all pretty uniformly worthless. :p