If you count all the "kill/no kill" choices, then there's actually almost 70 variations. The 16 that the devs mentioned are:

Iorveth:
- Stennis alive or dead
- Letho alive or dead

That gives 4 combinations

Roche:
- Anais given to Natalis
- Anais given to Radovid
- Anais taken by Roche (if you choose to help Triss)
- Letho alive or dead
- Henselt alive or dead

That's 12 combinations.
12+4=16. That's how I see it.
It's really inaccurate, because there's also the option to choose Triss over Iorveth, which gives 4 more combinations on Iorveth's side, then there's letting Sile live or die, which is 8 more combinations on Iorveth's side and 12 new combinations on Roche's side, and you can also kill or not kill the dragon on Roche's side, that's 24 new combinations and 4 on Iorveth's.
That's 68 possible combinations and that's only the major choices of who lives or dies.
If you count them all, it's actually

In my opinion you shouldn't count all of them but only the ones which affect the political situation most. Like Stennis' and Henselt's death/life choices as these choices affect the situation in the kingdoms these guys belong. Or choosing Triss over Iorveth / Roche as if you choose Triss a new "council of mages'"is established and if you don't choose Triss no new council is established and mages are getting arrested, or even worse being hunted.
And After a bit of thought i think Letho's life/death situation isn't an important part as it doesn't affect the political outcome much since he'll not meddle anymor whether he lives or not.

Geralt has a thing for sorceresses man. Always had, always will. It's probably the fact,that they are sterile just as he is, and live as long as he does.
All the mutations he went through in Kaer Morhen make him age really slow, and sorceresses, well, they simply overuse their power to look perfect no matter what and they stay young for a long long time. and Geralt, despite being the tough guy is pretty intellectual and has a romantic angle , a philisophic soul of a sort, a liking for torturing himself with doubts and conflicts.

Likewise. I was ready to kill him but when i heard he saved Triss, bah... What difference that would made. I spared him, also spared the dragon (Saskia) on that save either. Full of love :)

On my insane Run I might spare him. since I am going all out scoital route (including import save).

bros before hoes and all that.

Do we have any idea what happens to Anais and Roche when you're on the Iorveth path? Triss mentions Radovid trying to bribe Roche and being turned down, but nothing else. I guess with Demavend dead Anais is with...who?

I can't figure out which end is the 'best' if your aim is to repel the Nilfgaardians. Depends on what you think of the new Pontar state I reckon.

If you think it's a good thing (and I do, dragonqueen backed by powerful soceresses) then Iorveth path + save Triss is probably best, as the Conclave is established, Pontar state is established and even though Saskia is under the spell, you have the spellbreaking dagger + I'm pretty sure Shile and Philippa are going to help fight Nilfgaard.

Unfortunately no, which is a shame because Roche is awesome and Iorveth...well he's sort of a terrible guy but still a bit awesome.

no way for a peace between Iorveth and Vernon. Vernon calls him "a regular son of a whore" while Iorveth was telling "good" things about Vernon. Where are the manners?

Wasn't it implied that Radovid killed Anais' brother? I am sure she is in danger, unless she is with Roche. And Roche is claimed to be a war terrorist, IIRC.

I think saving Saskia is a good choice too. She will provide a valuable ally to other Northern Kingdoms, and I can see her using guerrilla warfare against Nildgaard together with Iorveth. Philippa would probably go back to side with her, since she has nowhere to go (not counting Francesca and her state) and their aims are similar. Not to mention, if you save Saskia, she doesn't seem to harbor any vengeful feelings against Eilhart, and is ready to move on, like if nothing happened between them. Sile should go teach biology on university, lol.

Honestly I can't see anything done will ultimately affect how 3 will play out as it currently is. If W2 outcome is to affect W3's storyline, you'd need a truly innovative and huge game, because W3 would have to have multiple starting points. Diverging story lines are great but there needs to be convergences to hem in the story basically forcing any prior choices into two possible outcomes to allow the story to then diverge again. W2 kind of got out of control at the end with all the possibilities. I don't think W2 is finished, and they'll are looking at converging the story so that W3 would feel like a continuation. Allowing you to decide letho's fate removes possible DLC of playing as him finding out the emperor has betrayed him. Same with Saskia. I'd assume if you'd free'd Saskia she'd go off, heal, and then go make a snack of Phillipa and Sile if they had lived.

So, and this is a question that contains spoilers...

Why did Geralt leave Loc Muinne alone? The ending originally shows him leaving with his companions, but you'll see him overlooking Loc Muinne, while those he was just with are searching for something(probably Geralt) near the entrance to the city. Does that signify he's going off after Yennifer and that's what the next expansion or DLC will be?

As far as Letho goes I think if they make a choice in W3 as to his fate, he would be alive. He was once the ally of Geralt, didn't kill him when he had the chance in Ch1, saves Triss if you choose to save others, and more than all of that, looked after Yennefer and protected her when Geralt was gone. Add to that Geralts disposition of "Witcher's hunt monsters not humans" and I don't see why Geralt would choose to kill Letho.

For my path I chose Iorveth, haven't decided if I let Stennis die, leaning toward the noose, I will free Saskia, and let Letho go in peace for saving both of the major women in my life.

I am really curious to see what happens when Yennefer is back and they both get their memories back. Would be interesting to find out Triss was a jealous element to their relationship in someday and took advantage of Geralts memory wipe.

That was my favourite ending combination too :) I got the impression that the bribe from Radovid had something to do with Anais as well, I guess we just have to hope she's going ok.

This is something I've been thinking about a lot as well, I'd thought the same sort of thing. It doesn't make as much sense if you rescued Triss and talked to her about loving her even after your memory returned, but I think it's the best answer we have at the moment. Must be a prelude to some sort of DLC though :)

Gaaahhh. I feel guilty now. I killed the dragon because I thought it was gonna suffer there anyways. And I let Sile go boom. And I left Iorveth to get Triss. hmmm...

I believe I read something about that just being a pug. One of the patch notes says that the NPC's now properly de-spawn at the end. I think in that scene they are leaving Loc Muinne and Geralt lingers for a moment to look back over the city before joining his companions. There were not supposed to be any NPC moving around down by the entrance.

Yeah good call, saw those patch notes and was thinking the same thing, makes a lot more sense now :)

I spared Letho. He is the coolest character. He played smart, and the witches thought he was dump because he looked like a big oaf.

He also spared Geralt's life. Don't think he's less bad than anyone in the witcher's world. It's a cruel world indeed.