When launching the game, it crashed when the Croteam logo appeared with the following error:

Fatal error: [File:E:\s\workspace\T2\UE5\Engine\Source\Runtime\D3D12RHI\Private\D3D12Util.cpp] [Line: 873] hr failed at E:\s\workspace\T2\UE5\Engine\Source\Runtime\D3D12RHI\Private\Windows\WindowsD3D12Viewport.cpp:252 with error 80070005

I managed to solve it by disabling frame generation (it actually runs way smoother on GOG w/o frame generation than it does on Steam for me!) in:

C:\Users\User\AppData\Local\Talos2\Saved\Config\Windows\GameUserSettings.ini

Look for "FrameGeneration" and set it to 0, so:

`FrameGeneration=0`