I downloaded mods and they don't work. I turn on all mods.
I have managed to install some of them, you have to unzip them in the folder C:\Users\YOUT Name\Documents\My Games\Binding of Isaac Afterbirth+ (Galaxy) Mods.
Not everyone of them will work (i haven't managed to get the item descriptions one working yet), but i have already installed a buncg and they worked perfectly.
Good luck and happy modding