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ThatNurgaWorm: I get sound on the intro, but no video. I've tried literally every solution listed on the Discussions board. I can't change the Graphic Mode through the setup utility because when I go to save those settings or launch the game with the settings, it says that the game is not installed. I've tried both a browser download/install and the GOG.com Downloader download/install, and I ran everything as an administrator. I am truly stuck.

I'm using Windows 7 64-bit. HELP.
Did you try reinstall it with "Run as administrator..." option?
I remember that this was a solution to all Syndicate problems.
If that wont work please send email to Support
"Refreshing" the screen by switching to windowed mode and back again looks like a good workaround, however all those issues you're describing with file access permissions suggest that
a) your Windows user account doesn't have Administrator privileges,
b) your User Account Control (UAC) is enabled and giving you a hard time.

Could you check this on your end? Ideally your account shoudl have Admin privileges and UAC should be off.