I wonder if the game can be changed via the developers or GOG to stop the behavior that triggers such a problem.
I avoid buying games based on this reason. I shouldn't have to white list a game because it was poorly programmed.
Its not poor programming, is usually just the heuristics scanner of AV's tagging something they shouldnt it happens doublely so if a virus scanner has to rapidly put out a update for some new virus.
It's not poorly programmed, it's the antivirus software that sometimes gets confused with part of the code. We released like 100 updates since we hit Early Access on Steam and on 2 updates antivirus had some problems. Not on all computers, just some. We had about 10 complaints on Steam forum and there are a little more then 100 000 people with Steam version of the game.
My Panda antivirus also complained that my Excel.exe is a virus. And I assure you, it's not Microsoft's fault, it's antivirus.
Just exclude the file from scan and that's it.
I had to do that with Excel, Shadow of Mordor, SWTOR... It's not uncommon. The only important thing is that you trust the software you install. If it's a original full version of the game, be it on GoG or Steam, you don't need to worry about whitelisting it. If it's something that just popped out of nowhere, of course you will quarantine it.
So it happens, viruses are just code in reality, they are programs which do unpleasant things.