Cantiras: Yes, TSLRCM is compatible with the Aspyr update to the game. If you already had KOTOR II installed prior to the Aspyr update, it is probably advisable to first update your game before installing TSLRCM.

Also, the fog is messed up in the Aspyr version; you might want to apply the ShaderOverride fix. You can find additional instructions at https://deadlystream.com/topic/5345-fog-and-speed-blur-fix-for-the-2016-tsl-patch [when Kexikus references the GOG version in the first post in that thread, he is referencing the previous (i.e. pre-Aspyr update) version of KOTOR II that used to be available on GOG]. The fog issue is noticeable some places in the vanilla Aspyr version, and is glaringly apparent if you install the M4-78 Enhancement Project mod.

As alluded to by RevanFan, you might also want to change "DisableVertexBufferObjects=1" to "Disable Vertex Buffer Objects=1" (without quotation marks) in the [Graphics Options] section of the swkotor2.ini file if you are bothered by the issue with lightsaber hilt textures in the Aspyr version (I've attached a clearer image of the issue to this post). However, changing this setting has caused crashes at certain points in the game for some people, so it might not be worth it to you. If you decide to change the setting to "Disable Vertex Buffer Objects=1", and your game later crashes, try reverting it back to "DisableVertexBufferObjects=1" to see if that resolves the issue. Once you are past a point where the game was crashing, you can once again change the setting to "Disable Vertex Buffer Objects=1". You may encounter multiple points in the game where it crashes if the setting is changed to "Disable Vertex Buffer Objects=1", so you may have to repeat this process a few times.

If you set the refresh rate (via Options > Graphics > Screen Resolution in the game menu, or by manually editing the RefreshRate setting in swkotor2.ini) to a high hertz value such as 144 Hz, you may encounter an issue in the Aspyr version whereby your character won't be movable after combat. PCGamingWiki recommends a maximum of 60 or 72 Hz, but I use a setting of 85 Hz with no issue (and in the previous non-Aspyr version, 85 Hz was the maximum I could select). I have VSync enabled.

You can also use the 4GB Patch tool on swkotor2.exe.

The only mods I routinely have installed are:
1) TSL Restored Content Mod
2) Unofficial TSLRCM Tweak Pack (I don't install the whole Tweak Pack mod; I only replace Kaevee with Jorran using the the individual component installer included with the mod)
3) Extended Enclave (TSLRCM add-on)
4) TSLRCM Icon Fix

Cantiras: 4) TSLRCM Icon Fix

LusoGamer: You don't need this mod. Just go the the override folder and delete the file kotor2logo.tga

Cantiras: Actually, that's a misidentification of a mod on my part. TSL Main Menu Model Fix for Widescreen 1.2 is the mod I intended. It adjusts the logo and title fog at widescreen resolutions.