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This doesn't ha[[en when the game first starts, but when I try to load game from the menu while playing it will crash more than half the time. I've uninstalled/reinstalled and my security settings are valid. I am using Win 10 with Windows Anti-Virus. Any help?
crash during game load = lack of ram... it could be that your system isn't allowing SR2 to use the ram or that it just doesn't have it

so we are on the same page, what version of the game are you using i.e, Galaxy, gog offline installers or the free open released files?