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I started a custom game a while back, and it's gotten absurd. I'm at level 25 blights, and approaching 1300 levels. I expected the handicaps to ultimate outstrip my growth, particularly when I ran out of relics, but it's been getting easier recently.

Is there any point to playing on, or should I just abandon the run? Maybe acheivements, or interesting things that happen super deep into the game?

It's been fun, and part of me wants to stick with it because of how much I've already invested. However, I feel like I've run out of things to explore.

P.S. It's certainly a combination of luck and the options I set, I'm not an amazing player.
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Wow, that's insane! you must have had a good card combo. I used to prioritize relics, but lately I've been prioritizing good cards. It would be neat to have an option to save runs in different slots, so you could keep the run on the side while starting a new one. It would have come in handy when I was playing on the same computer as my sister.
I too used to prioritize relics, but I've found cards is the gravy and relics take or leave them. The last run, I got a special encounter I think that transformed my strikes and defense too. I got cards I would never have taken before. But since I had them, I had to work with them and not having plain strikes and plain defense cards really, really helped. I ascended. I doubt that will happen on my next run, but card selection for my next run will be different for sure, since I know more how to use (read abuse) them. <Silent>