dnovraD: Toggle Directdraw in the ini. If that doesn't work, maybe try WSL, installing Gamescope, and then running it via Wine in Gamescope.
I enabled direct draw (in Alpha Centauri.ini I set: DirectDraw=1)
Same error.
Full error text is:
FATAL ERROR
Windows has run out of virtual memory; the game will exit.
Recommendations: defragment your hard drive; use Control Panel (System/Performance/Virtual Memory) to increase your virtual memory to at least 128MB
For the record, my virtual memory is in the gigabytes and managed by windows, so its size is dynamic.