Phalmy: RE: blind research
If you're new to the game, by all means, switch it off. There's no need to make things more arcane than they need to be. But once you develop a feeling for the different paths and beelines, blind research makes the game a lot more interesting (the bar is red! please, please be Neural Grafting...) because you have to prepare for a variety of different outcomes, not just the one you want.
Meh, when i was new to the game, i had the blind research on. It's even more fun when you completely don't know what future techs will look like, what they will give you etc. That feeling of not knowing what future holds... it happens only once in the lifetime, don't waste it. Knowing the techs is like a spoiler to me :P That feeling when you explore the planet, not knowing what this fungus thing is, encountering indigenous life for the first time... Man.... You really FEEL like on an alien planet. And it didn't make things THAT much harder - I still won the game on the default difficulty (maybe on the second attempt, becouse first i had to figure out the interface). Good old times...