I'm currently playing through Sherlock Holmes: The Awakened, and I'm inside the mansion in the French district in New Orleans.

There's a master bedroom with a puzzle partially filled in, and I've read there's a safe in here somewhere that reveals itself once you've got everything in the room, but it hasn't revealed itself? I'm not sure where to look either.

Sorry if there is a really simple solution, but I've been stuck on this for a while.

Ah OK, I solved it! But if anyone else has the same issue as I did - struggling to find the safe in the master bedroom - it reveals itself once you've interacted with everything around the house including picking the flowers in the garden (there's a cutscene where it opens and Watson prompts Sherlock to come back to the room)! I seemed to have walked past a flower that I needed to pick up lol.

It might've just been me but I didn't feel like the in-game guide was as clear as it could've been regarding the safe!